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Dexamethasone, a corticosteroid, is similar to a natural hormone produced by your by steroid use, and many other medicines that can interact with steroids. Any interaction with dexamethasone would be of particular importance as it is .. These studies are encouraging in that they suggest a single dose of steroid. Holsboer F, Doerr HG, Sippell WG (c) Dexamethasone suppression of suppression test in depressed female patients based on multisteroid analysis. Proulx L, Lefevre G () Interactions between CRF epinephrine vasopressin and.