Cellular mechanism of hormone action
Chemical proteomics strategies for elucidation of cellular steroid hormone targetsURN zum Zitieren dieses Dokuments: Annals of the Rheumatic Diseases 71, S. To explore changes in the number of steroid hormone receptor positive cells in synovial tissue ST after intra-articular glucocorticoid injection, to correlate these androgen and testosterone are same with changes in clinical variables, and to evaluate whether the number of steroid hormone receptor steroid hormone effect on cell cells predicted the clinical response to glucocorticoid injection. Fourteen patients with persistent knee arthritis despite at least two previous injections in an outpatient setting received steroid hormone effect on cell intra-articular injection with glucocorticoids, followed by 3 days of admission with bed rest. Clinical efficacy was assessed at 6 and 12 weeks. ST biopsies were performed 2 weeks before and 12 weeks after the injection.
You have sent too many requests causing Linguee to block your computer
Klug; Steroid hormone receptors: Steroid hormones SHs are lipophilic molecules derived from cholesterol and synthesized in the adrenal cortex glucocorticoids, mineralocorticoids, and adrenal androgens , the testes testicular androgens, oestrogen , and the ovary and placenta oestrogens and progestagens or progestins. SHs reach their target cells via the blood, where they are bound to carrier proteins, and because of their lipophilic nature pass the cell membrane by simple diffusion.
Within the target cells SHs bind to steroid hormone receptors SHRs , the key mediators of SH action, which are complexed to chaperones, e. SHRs are intracellular transcription factors that can be activated, among other possibilities, by the specific and high affinity binding of ligand to exert positive or negative effects on the expression of target genes. Binding of agonistic or antagonistic ligands leads to different allosteric changes of SHRs making them competent to exert positive or negative effects on the expression of target genes by different mechanisms.
The HRE-recruited hormone-receptor-complexes are then able to initiate chromatin remodelling and to relay activating or repressing signals to the target genes transcription machinery; ii through protein—protein interactions with other sequence-specific transcription factors, SHRs can also regulate the activity of many genes that are switched on, for instance, during stress or an inflammatory response; iii the SH response can also be integrated in the intracellular signalling network via cross-talk of SHRs with signal transduction pathways that transmit extracellular signals via membrane receptors and activation of protein kinase cascades to nuclear transcription factors that activate various target genes.
By all these different mechanisms SHRs modulate numerous and specific responses in a large variety of cells, whereby their particular effect depends on the physiological, cellular and genetic context. Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Close mobile search navigation Article navigation. Abstract Steroid hormones SHs are lipophilic molecules derived from cholesterol and synthesized in the adrenal cortex glucocorticoids, mineralocorticoids, and adrenal androgens , the testes testicular androgens, oestrogen , and the ovary and placenta oestrogens and progestagens or progestins.
Email alerts New issue alert. Receive exclusive offers and updates from Oxford Academic. More on this topic Transcriptional regulation of early oogenesis: Related articles in Web of Science Google Scholar.
Studying on the strictly self-compatibility mechanism of 'Liuyefeitao' peach Prunus persica L. Genome-wide identification and expression profiling of the auxin response factor ARF gene family in physic nut. Citing articles via Web of Science Latest Most Read Most Cited Understanding variation in prevalence estimates of polycystic ovary syndrome: Epigenetic regulation in development: Clinical relevance of genetic variants of gonadotrophins and their receptors in controlled ovarian stimulation: The contribution of human sperm proteins to the development and epigenome of the preimplantation embryo.
Steroid hormone receptors: an update | Human Reproduction Update | Oxford Academic
Oestrogens are best known for their effects upon the female reproductive system, However, these steroid hormones are also essential for sperm production in males, The biological actions of oestrogens are only found in cells expressing . De novo steroid hormone biosynthesis is realized via a cascade of reactions with The effect of sulfated steroids and of intermediates and end products of the steroid cell cultures co-expressing the CYP11A1 and CYP17 systems, steroid. Chemical proteomics strategies for elucidation of cellular steroid hormone targets of steroid hormone effects mediated by other cellular target structures lacks.